Oxford University Press, Social Cognitive and Affective Neuroscience, 11(9), p. 1845-1854, 2014
DOI: 10.1093/scan/nst183
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Adolescence is a crucial period for the development of adaptive emotion regulation strategies. Despite the fact that structural maturation of the prefrontal cortex during adolescence is often assumed to underlie the maturation of emotion regulation strategies, no longitudinal studies have directly assessed this relationship. This study examined whether use of cognitive reappraisal strategies during late adolescence was predicted by i). absolute prefrontal cortical thickness during early adolescence and ii). structural maturation of the prefrontal cortex between early and mid-adolescence. Ninety-two adolescents underwent baseline and follow-up MRI scans when they were approximately 12 and 16 years old, respectively. FreeSurfer software was used to obtain cortical thickness estimates for three prefrontal regions (anterior cingulate cortex, ACC; dorsolateral prefrontal cortex, dlPFC; ventrolateral prefrontal cortex, vlPFC). The Emotion Regulation Questionnaire was completed when adolescents were approximately 19 years old. Results showed that greater cortical thinning of the left dlPFC and left vlPFC during adolescence was significantly associated with greater use of cognitive reappraisal in females, though no such relationship was evident in males. Furthermore, baseline left dlPFC thickness predicted cognitive reappraisal at trend level. These findings suggest that cortical maturation may play a role in the development of adaptive emotion regulation strategies during adolescence.