The BIS2 GFR estimating equation was recently developed for an elderly population. We evaluated whether this equation improved risk reclassification for the primary end point of all-cause death and secondary end points of cardiovascular death/events when compared to the CKD-EPI equation based on KDIGO GFR categorization among 1,017 individuals aged 71 to 75 years within the population-based ESTHER study. We found a systematic bias; eGFR computed using BIS2 compared to using CKD-EPIcr-cys was lower at eGFR greater than w40 mL/min/1.73 m2, but higher at lower eGFR. BIS2 reclassified patients to more advanced eGFR categories irrespective of whether they went on to have the adverse event or not. Compared to CKD-EPIcr-cys, BIS2 does not appear to improve risk classification for all-cause death or cardiovascular disease in the elderly.