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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(59), p. 734-737, 2015

DOI: 10.1128/aac.03647-14

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In Vivo Selection of Plasmodium falciparum Pfcrt and Pfmdr1 Variants by Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine in Burkina Faso

Journal article published in 2015 by Vito Baraka, Halidou Tinto, Innocent Valea ORCID, Robert Fitzhenry, Christopher Delgado-Ratto, Martin K. Mbonye, Chantal Van Overmeir, Anna Rosanas-Urgell, Jean-Pierre Van geertruyden, Umberto D'Alessandro, Annette Erhart
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Plasmodium falciparum Pfcrt -76 and Pfmdr 1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt -K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr 1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.