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Wiley, FEBS Letters, 10(583), p. 1619-1624, 2009

DOI: 10.1016/j.febslet.2009.04.031

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Transient receptor potential vanilloid‐1 signaling inhibits differentiation and activation of human dendritic cells

Journal article published in 2009 by Balázs I. Tóth ORCID, Szilvia Benkő, Attila G. Szöllősi, László Kovács, Éva Rajnavölgyi, Tamás Bíró
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The goal of the current study was to investigate the expression of transient receptor potential vanilloid-1 (TRPV1) on human in vitro differentiated monocyte-derived dendritic cells (DCs) and to dissect the corresponding role of TRPV1-signaling in DC-specific functions. TRPV1 expression was identified both at the protein and gene levels in human DCs. Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. These data introduce TRPV1-coupled signaling as a novel player in human monocyte-derived DC biology with anti-inflammatory actions.