Dissemin is shutting down on January 1st, 2025

Published in

Springer Nature [academic journals on nature.com], Eye, 2(27), p. 137-141, 2012

DOI: 10.1038/eye.2012.252

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Ocular metastases

Journal article published in 2012 by V. M. L. Cohen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The eye is a rare site for disseminated malignancy because of the absence of a lymphatic system. Metastases to the ocular structures occur by haematogenous spread and therefore the parts of the eye with the best vascular supply are most likely to be affected. Many patients with Stage 4 carcinomatosis (distal metastatic spread) already have a history of a previous primary cancer. However, this is not always the case for lung cancer as this can metastasise early to the uveal tract and therefore the ophthalmologist may be the first to discover the presence of terminal metastatic disease. Broadly speaking, treatment options are focused on improving the patients' quality of life if visual acuity is threatened. Long-term side effects of treatment need to be considered as systemic cancer treatments and therefore patient life expectancy is improving. In this manuscript, presented at the Cambridge symposium 2012, the diagnosis and challenges involved in the management of ocular metastases are presented.