The size distribution and morphology of particles (dense or hollow) produced from polydispersed droplets in spray pyrolysis were studied both experimentally and theoretically. Zirconia, generated from a zirconyl hydroxychloride precursor, was selected as a model material. The simulation method that was previously developed by our group [J. Mater. Res., 15, 733 (2000)], in which droplets were assumed to be uniform, was improved to evaluate the effect of polydispersity in droplets on the size and morphology of the resulting particles. Simultaneous equations for heat and mass transfer of solvent evaporation and solute mass transfer inside droplets were solved numerically for a number of discrete classes of droplet size distribution. The role of the decomposition reaction was also included after the evaporation stage of polydispersed droplets in an attempt to explain the densification of particles. In hollow particle generation, this simulation was used to evaluate the thickness of a particle shell. The experimental results were in good agreement with the simulation data, suggesting that the model provides a more realistic prediction.