Elsevier, Journal of Neuroimmunology, 1-2(274), p. 202-208, 2014
DOI: 10.1016/j.jneuroim.2014.07.006
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Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n = 41) compared to the antibody-negative patients (n = 108). Autoantibodies detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings.