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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(59), p. 7782-7785, 2015

DOI: 10.1128/aac.01375-15

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Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68

Journal article published in 2015 by Liang Sun, Adam Meijer, Mathy Froeyen, Linlin Zhang, Hendrik Jan Thibaut ORCID, Jim Baggen ORCID, Shyla George, John Vernachio, Frank J. M. van Kuppeveld, Pieter Leyssen, Rolf Hilgenfeld, Johan Neyts, Leen Delang
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A structural explanation of why both substitutions may cause resistance is provided.