Pore fluid pressure is an important parameter defining the mechanical strength of marine sediments. Obtaining high spatial resolution in situ pore pressure measurements in marine sediments, however, is a challenge, and as a result, only a handful of in situ pore pressure measurements exist at scientific drill sites. Integrating rock physics models with standard IODP measurements provides a potentially widely applicable approach for calculating in situ pore pressure. Here, we use a rock physics approach to estimate in situ pore pressure at two Scientific Ocean Drill Sites where in situ pressure is well-constrained: ODP Site 1173, used as reference for normal (hydrostatic) fluid pressures, and ODP Site 948, where previous studies infer high fluid pressures (λ*∼ 0.45-0.95, where the pore pressure ratio λ* is defined as the pore pressure above hydrostatic divided by the difference between the largest principal stress and hydrostatic stress). Our analysis indicates that the rock physics method provides an accurate, low-precision method for estimating in situ pore pressure at these drill sites, and sensitivity analysis indicates this method can detect modestly high (λ*>0.6) pore pressure at the 95% confidence level. This approach has broad applicability because it provides an inexpensive, high-resolution (meter-scale) method for retrospectively detecting and quantifying high pore pressure at any drill site where quality wire-line logs and ocean drilling data exists. This article is protected by copyright. All rights reserved.