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American Chemical Society, Journal of Organic Chemistry, 21(79), p. 10311-10322, 2014

DOI: 10.1021/jo501930s

Wiley-VCH Verlag, ChemInform, 16(46), p. no-no, 2015

DOI: 10.1002/chin.201516250

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Access to 4-Alkylaminopyridazine Derivatives via Nitrogen-Assisted Regioselective Pd-Catalyzed Reactions

Journal article published in 2014 by Emilie Blaise, João Xavier de Araújo-Júnior, Arthur E. Kuemmerle, Arthur E. Kümmerle, Hassan Hammoud, J. X. De Araújo-Júnior ORCID, Frédéric Bihel ORCID, Jean-Jacques Bourguignon, Martine Schmitt
This paper is available in a repository.
This paper is available in a repository.

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Abstract

3-substituted, 6-substituted and unsymmetrical 3,6-disubstituted 4-alkylaminopyridazines were prepared from a sequence of three chemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions. Extension of the methodology to Sonogashira reaction yielded a novel class of 3-substituted pyrolopyridazines.