Published in
American Society for Microbiology, Journal of Virology, 14(82), p. 7243-7247, 2008
DOI: 10.1128/jvi.00307-08
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Rhesus Macaque TRIM5 Alleles Have Divergent Antiretroviral Specificities
Journal article published in 2008 by
Sam J. Wilson,
Benjamin L. J. Webb,
Charlotte Maplanka,
Ruchi M. Newman,
Ernst J. Verschoor,
Jonathan L. Heeney,
Greg J. Towers 
This paper is made freely available by the publisher.
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Abstract
ABSTRACT TRIM5α is a potent barrier to cross-species retroviral transmission, and TRIM5αs from different species have divergent antiretroviral specificities. Multiple TRIM5 alleles circulate within rhesus macaque populations. Here we show that they too have different antiretroviral specificities, highlighting how TRIM5 genotypes contribute to protection in an individual or a population.