Dissemin is shutting down on January 1st, 2025

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Current Issues in Pharmacy and Medical Sciences, 1(25), p. 72-75

DOI: 10.12923/j.2084-980x/25.1/a.17

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Influence of sterilization on the rheological properties of different types polyacrylic acid gels

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The aim of the study was to analyze the influence of sterilization conditions on the rheological properties of gels containing polyacrylic acid derivatives (Carbopols: 974P, Ultrez 10 and Ultrez 20). The gels utilized in this study contained 0.5% (w/w) metronidazole, antiprotozoal drug (model drug substance). Their rheological properties were determined: flow curve, yield point, apparent viscosity. Moreover, a statistical analysis of factors (polymer type, polymer concentration, sterilization by autoclaving) was undertaken, and their impact on viscosity, yield point and area under flow curve was ascertained. Among this polymers, gels comprising Carbopol 974P were the most stable to sterilization conditions.