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BioMed Central, Breast Cancer Research, 4(10), 2008

DOI: 10.1186/bcr2111

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Breast cancer stem cells: implications for therapy of breast cancer

Journal article published in 2008 by Brian J. Morrison, Chris W. Schmidt, Sunil R. Lakhani ORCID, Brent A. Reynolds, Lopez J. Alejandro, J. Alejandro Lopez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumourassociated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells. Published: 22 July 2008 © 2008 BioMed Central Ltd