n-Propanol, 2-propanol, 1,2-propanediol, 1,3-propanediol, and glycerol are all saturated alcohols with a three-carbon atom chain. The difference between them is the number of hydroxyl groups and their positions in these mol-ecules. The interaction between alcohols with a three-carbon atom chain and model surfaces and the further reaction have been widely investigated in the last three decades. In this short review, we will concentrate our attention on the reactivity of n-propanol, 2-propanol, 1,2-propanediol, 1,3-propanediol, and glycerol on smooth Pt in acidic medium. We will present the most important results reported in the literature in this field, highlighting the main particularities related to their reactions, addressing key points such as the impact of the position of the OH group in the molecule, number of OH groups in the molecule, and presence of vicinal OH groups in the molecule on the reactivity of these alcohols over Pt. Finally, we will present some perspectives concerning the application of alcohols with a three-carbon atom chain, mainly glycerol, in fuel cells.