Published in
Lippincott, Williams & Wilkins, Journal of Pediatric Hematology/Oncology, 7(33), p. e264-e266, 2011
DOI: 10.1097/mph.0b013e31821754ac
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Dysmegakaryopoiesis, a Clue for an Early Diagnosis of Familial Platelet Disorder With Propensity to Acute Myeloid Leukemia in Case of Unexplained Inherited Thrombocytopenia Associated With Normal-sized Platelets
,
Philippe Jonveaux,
Thomas Lecompte,
Rémi Favier
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Abstract
We report dysmegakaryopoiesis in a case of familial platelet disorder with predisposition to acute myeloid leukemia (familial platelet disorder/acute myeloid leukemia phenotype Mendelian Inheritance in Man number 601 399). Slight reduction of the number of megakaryocytes with high nucleocytoplasmic ratio, strongly basophilic cytoplasm and poorly lobulated nuclei are suggestive of megakaryocytic dysplasia.