Dissemin is shutting down on January 1st, 2025

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Cell Press, Trends in Immunology, 9(35), p. 420-428, 2014

DOI: 10.1016/j.it.2014.07.006

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Antiviral innate immunity and stress granule responses

Journal article published in 2014 by Koji Onomoto, Mitsutoshi Yoneyama ORCID, Gabriel Fung, Hiroki Kato, Takashi Fujita
This paper is available in a repository.
This paper is available in a repository.

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Data provided by SHERPA/RoMEO

Abstract

Viral infection triggers the activation of antiviral innate immune responses in mammalian cells. Viral RNA in the cytoplasm activates signaling pathways that result in the production of interferons (IFNs) and IFN-stimulated genes. Some viral infections have been shown to induce cytoplasmic granular aggregates similar to the dynamic ribonucleoprotein aggregates termed stress granules (SGs), suggesting that these viruses may utilize this stress response for their own benefit. By contrast, some viruses actively inhibit SG formation, suggesting an antiviral function for these structures. We review here the relationship between different viral infections and SG formation. We examine the evidence for antiviral functions for SGs and highlight important areas of inquiry towards understanding cellular stress responses to viral infection.