The burden of disease was estimated in people affiliated to the Mexican Social Insurance Institute -IMSS- in 2000.Main results: Similarities with AMRO A subregion and Australia in first causes of burden, total DALY and years lost due to premature mortality; similarities with AMRO B and D subregions in disability live expectancy; highest socioeconomic development associated with highest magnitude of years lived with disability and disability live expectancy at federative entities level. Conclusion: An unexpective high burden of morbidity with disability was found in people affiliated to IMSS; in federative entities, the burden of morbidity is associated with socioeconomic level. These results permit to infer, ecologically, that this population is experimented low levels of mortality with an expansion of morbidity.