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Elsevier, Structure, 3(20), p. 385-387, 2012

DOI: 10.1016/j.str.2012.02.005

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Ob-Stopping Obesity, Metabolic and Immune-Mediated Disorders

Journal article published in 2012 by Giuseppe Matarese ORCID, Veronica De Rosa ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally characterized before. In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb).