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Royal Society of Chemistry, RSC Advances, 12(5), p. 8585-8590, 2015

DOI: 10.1039/c4ra11884g

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Acid-responsive nanospheres from an asparagine-derived amphiphile

Journal article published in 2014 by Adelphe M. Mfuh, Mathew P. D. Mahindaratne, Audrey E. Yñigez Gutierrez, Juan R. Ramos Dominguez, Jefferson T. Bedell Ii, Jefferson T. Bedell Ii, Carlos D. Garcia ORCID, George Raymond Negrete
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.