Published in
Elsevier, Tetrahedron: Asymmetry, 8(9), p. 1381-1387
DOI: 10.1016/s0957-4166(98)00111-6
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Enantioselectivity in the reduction of tricyclic hydroaromatic ketones by baker's yeast
Journal article published in 1998 by
Gabriele Fontana,
Paolo Manitto,
Giovanna Speranza 
,
Simona Zanzola
,
Simona Zanzola
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Abstract
Three benzo-2-tetralones were hydrogenated to the corresponding alcohols by non-fermenting baker's yeast. Satisfactory yields but modest enantioselectivities were observed. The prevalent enantioform of the benzo-2-tetralol was found to be in agreement with the predictive abstract model previously proposed for the enzymatic hydrogenation of aromatic ring substituted 2-tetralones.