Handshaking represents a complex motor and cognitive task that poses several challenges from both engineering and neuroscientific viewpoints. In particular, it is an intriguing application which can be profitably studied in the field of Human Robot Interaction (HRI). In this work an experimental paradigm is proposed to investigate the neural correlates of handshaking between humans and between humans and robots using functional Magnetic Resonance Imaging. More specifically the role of visual and haptic components during handshaking interaction will be studied. A wearable sensing glove will be used to monitor hand finger position and movement. Preliminary results will be reported and discussed.