The Canadian Cardiovascular Society (CCS) is implementing the Canadian Heart Health Strategy and Action Plan recommendation to build knowledge infrastructure, through its Data Dictionary and Quality Indicator (QI) project. CCS selected cardiac rehabilitation (CR) and secondary prevention as a content area for QI development. In accordance with the CCS QI Best Practice Methodology, rapid reviews of the literature were conducted. A long list of 37 QIs, in the areas of structure, process and outcome were developed. Through an online survey, 26 (42%) of all contacted external experts rated each QI on importance, scientific acceptability, and feasibility, using a 7-point scale. The overall mean rating was 5.4±1.4. Through a consensus process, the working group excluded 8 QIs based on this feedback, and several others were revised. A 30-day web consultation was then undertaken, to solicit input from the broader CCS and CR community. A “top five” list of QIs was requested by CCS, which were: (1) Inpatients referred to CR, (2) wait times from referral to CR enrollment, (3) Patient self-management education, (4) Increase in exercise capacity, and (5) Emergency response strategy. Knowledge translation activities are now underway to promote utilization of the QIs and ultimately improve CR care.