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Springer, Pharmaceutical Chemistry Journal, 9(47), p. 459-463, 2013

DOI: 10.1007/s11094-013-0980-8

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Synthesis and Anti-HIV-1 Activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil Derivatives

Journal article published in 2013 by M. P. Paramonova, D. A. Babkov, V. T. Valuev Elliston, A. V. Ivanov, S. N. Kochetkov, C. Pannecouque, A. A. Ozerov, J. Balzarini, M. S. Novikov
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This paper is available in a repository.

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Abstract

1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar amounts of 2,4-bis(trimethylsilyloxy)pyrimidine and 1-halo-ω-(phenoxy)alkane or -alkene in order to discover new non-nucleoside inhibitors of HIV-1 reverse transcriptase. Their anti-HIV-1 activity was studied in CEM-cell culture and against HIV-1 reverse transcriptase. It was found that several compounds exhibited marked activity.