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Elsevier, Cell Stem Cell, 2(15), p. 118-120, 2014

DOI: 10.1016/j.stem.2014.07.010

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Tipping the Balance: MTDH-SND1 Curbs Oncogene-Induced Apoptosis and Promotes Tumorigenesis

Journal article published in 2014 by Nagarajan Kannan ORCID, Connie J. Eaves
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.