American Chemical Society, Organic Letters, 22(11), p. 5114-5117, 2009
DOI: 10.1021/ol901862h
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Thermodynamic and kinetic calculations have been used to reinterpret the UV-vis data related to the OH radical oxidation of guanosine. The main channel of reaction (70-75%) is proposed to be the formation of a guanosine radical cation followed by deprotonation. It accounts for both the absorbance decay at approximately 620 nm and the build-up at approximately 300 nm. A secondary channel yielding the G8OH adduct was found to contribute to the overall reaction by 12% at least.