Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 43(110), p. 17456-17461, 2013
Links
- National Academy of Sciences
- ORCID
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies
Journal article published in 2013 by
Joshua M. Donaldson 
,
Cindy Zer,
Kendra N. Avery,
Krzysztof P. Bzymek,
David A. Horne,
John C. Williams
,
Cindy Zer,
Kendra N. Avery,
Krzysztof P. Bzymek,
David A. Horne,
John C. Williams
This paper is made freely available by the publisher.
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Abstract
Significance The identification and subsequent grafting of a unique peptide binding site within the Fab domain offers a unique means of adding functionality to monoclonal antibodies through a noncovalent interaction including improved pretargeted imaging, alternative payload delivery, and cross-linking of mAbs on cell surfaces to enhance their therapeutic potential.