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Oxford University Press, Human Molecular Genetics, R2(20), p. R109-R115, 2011

DOI: 10.1093/hmg/ddr336

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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises

Journal article published in 2011 by Maria C. Marchetto, Kristen J. Brennand ORCID, Leah F. Boyer, Fred H. Gage
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.