This study examines the sensitivity of a mid-size basin’s temperature and precipitation response to different global and regional climate circulation patterns. The implication of the North Atlantic Oscillation (NAO), El Niño Southern Oscillation (ENSO), Indian Monsoon and ten other teleconnection patterns of the Northern Hemisphere are investigated. A methodology to generate a basin-scale, long-term monthly surface temperature and precipitation time series has been established using different statistical tests. The Litani River Basin is the focus of this study. It is located in Lebanon, east of the Mediterranean Basin, which is known to have diverse geophysical and environmental characteristics. It was selected to explore the influence of the diverse physical and topographical features on its hydroclimatological response to global and regional climate patterns. We also examine the opportunity of conducting related studies in areas with limited long-term measured climate and/or hydrological data. Litani's monthly precipitation and temperature data have been collected and statistically extrapolated using remotely sensed data products from satellites and as well as in situ gauges. Correlations between 13 different teleconnection indices and the basin’s precipitation and temperature series are investigated. The study shows that some of the annual and seasonal temperature and precipitation variance can be partially associated with many atmospheric circulation patterns. This would give the opportunity to relate the natural climate variability with the watershed’s hydroclimatology performance and thus differentiate it from other anthropogenic induced climate change outcomes.