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Public Library of Science, PLoS ONE, 12(6), p. e29263, 2011

DOI: 10.1371/journal.pone.0029263

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Plasma Biomarkers for Detecting Hodgkin's Lymphoma in HIV Patients

Journal article published in 2011 by Susan M. Varnum, Bobbie-Jo M. Webb-Robertson ORCID, Nancy A. Hessol, Richard D. Smith ORCID, Richard C. Zangar
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The lifespan of people with human immunodeficiency virus (HIV) infection has increased as a result of effective antiretroviral therapy, and the incidences of the AIDS-defining cancers, non-Hodgkin's lymphoma and Kaposi sarcoma, have declined. Even so, HIV-infected individuals are now at greater risk of other cancers, including Hodgkin's lymphoma (HL). To identify candidate biomarkers for the early detection of HL, we undertook an accurate mass and elution time tag proteomics analysis of individual plasma samples from either HIV-infected patients without HL (controls; n = 14) and from HIV-infected patient samples with HL (n = 22). This analysis identified 60 proteins that were statistically (p