The aim of this work was to define the typical sensory profile of DOP Mozzarella di Bufala Campana cheese as related to the technological process (industrial or artisanal), the geographical area (Salerno or Caserta), the season (spring or summer) and to the chemical composition of both milk and cheese. The results obtained showed that the sensorial profile of Mozzarella DOP changed for each variable considered. In particular, Caserta samples were more salty, with a more intense butter odour, higher peelability and homogeneity surface than those from Salerno area; the industrial samples, compared to the artisanal ones, were more salty, hard and “chewable”, and exhibited an external layer more difficult to remove and more homogeneous.