The endangered black-footed ferrets primarily rely on prairie dogs to meet their dietary requirements. The existence of their food source, colonies of prairie dogs, is often threatened by periodic epizootics of the bacterium Yersinia pestis. To mitigate the potential loss of prairie dogs and ensure the survival of black-footed ferrets, wildlife managers are left with few tools such as pesticides or vaccines. Hand vaccination of individual prairie dogs would not be a viable tool in controlling plague due to the amount of labor and the cost to vaccinate a colony of prairie dogs. Currently, there are no registered oral vaccines for prairie dogs, though one is being field tested for potential registration. Thus wildlife managers must rely on dusting with pesticides for vector control. Dusting enhances the chance for survival from plague in prairie dog populations which in turn provides a food source for black-footed ferret survival. We will review the history of dusting prairie dogs up through the last fiscal year as agencies and wildlife managers fight to ensure prairie dog survival for black-footed ferret recovery.