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Elsevier, Diagnostic Microbiology and Infectious Disease, 3(71), p. 304-308

DOI: 10.1016/j.diagmicrobio.2011.07.002

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Matrix-assisted laser desorption/ionization time-of-flight intact cell mass spectrometry to detect emerging pathogenic Candida species

Journal article published in 2011 by Cledir Santos ORCID, Nelson Lima, Paula Sampaio, Célia Pais ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Matrix-assisted laser desorption/ionization time-of-flight intact cell mass spectrometry (MALDI-TOF-ICMS) was used to differentiate pathogenic Candida species, difficult to identify by traditional methods such as growth and biochemical reactions. Results showed that species complexes like C. parapsilosis, C. orthopsilosis, and C. metapsilsosis, and very closely related species like C. glabrata and C. bracarensis, and C. albicans and C. dubliniensis could be clearly separated. MALDI-TOF-ICMS stands out as a promising tool for the rapid detection of emerging pathogens.