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Society of Photo-optical Instrumentation Engineers, Journal of Biomedical Optics, 6(18), p. 060507

DOI: 10.1117/1.jbo.18.6.060507

Diffuse Optical Imaging IV

DOI: 10.1117/12.2032456

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Optical identification of subjects at high risk for developing breast cancer

Journal article published in 2013 by Paola Taroni, Giovanna Quarto, Antonio Pifferi ORCID, Lorenzo Spinelli, Alessandro Torricelli ORCID, Francesca Ieva, Giovanna Quartu, Anna Maria Paganoni, Francesca Abbate, Nicola Balestreri, Nicola Balestrieri, Simona Menna, Enrico Cassano, Rinaldo Cubeddu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A time-domain multiwavelength (635 to 1060 nm) optical mammography was performed on 147 subjects with recent x-ray mammograms available, and average breast tissue composition (water, lipid, collagen, oxy- and deoxyhemoglobin) and scattering parameters (amplitude a and slope b) were estimated. Correlation was observed between optically derived parameters and mammographic density [Breast Imaging and Reporting Data System (BI-RADS) categories], which is a strong risk factor for breast cancer. A regression logistic model was obtained to best identify high-risk (BI-RADS 4) subjects, based on collagen content and scattering parameters. The model presents a total misclassification error of 12.3%, sensitivity of 69%, specificity of 94%, and simple kappa of 0.84, which compares favorably even with intraradiologist assignments of BI-RADS categories.