Low surface energy fluorocarbon polymer coatings were prepared via plasma enhanced chemical vapor deposition (PECVD) of 1H,1H,2H,2H-perfluorodecyl acrylate (PFDA) in a low pressure inductively excited RF plasma. The influence of plasma parameters, such as, deposition time, continuous wave (CW) and pulse modulated (PM) plasma mode, plasma power and plasma duty cycle (DC) on morphology and wettablity of the PFDA was investigated using field emission scanning electron microscopy (FESEM) and contact angle (CA) measurement techniques. The plasma mode, plasma power and pulse duty cycle played a pivotal role in tailoring the surface morphology, wettability and the surface energy of the PFDA coating. The water CA hysteresis values for PFDA coatings suggested the wetting characteristics of the coating satisfying Wenzel model of nanostructured solid-water wetted contact. A thin conformal PFDA coating transformed a super-hydrophilic Whatman filter paper into a super-hydrophobic and oleophobic surface, which has industrial applications for development of durable, stain resistance and liquid repellent papers. The antifouling property of PFDA coatings investigated by quartz crystal microbalance (QCM) exhibited the protein repellent behavior against three model proteins namely, ovalbumin (OVA), human serum albumin (HSA) and fibrinogen (FGN).