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Public Library of Science, PLoS ONE, 4(7), p. e34902, 2012

DOI: 10.1371/journal.pone.0034902

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Association of Spermatogenic Failure with the b2/b3 Partial AZFc Deletion

Journal article published in 2012 by Abdelmajid Eloualid, Houria Rhaissi, Ahmed Reguig, Safaa Bounaceur, Brahim El houate, Brahim El Houate, Omar Abidi, Majida Charif, Noureddine Louanjli, Elbakkay Chadli, Abdelhamid Barakat, Anu Bashamboo, Ken McElreavey, Hassan Rouba
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Infertility affects around 1 in 10 men and in most cases the cause is unknown. The Y chromosome plays an important role in spermatogenesis and specific deletions of this chromosome, the AZF deletions, are associated with spermatogenic failure. Recently partial AZF deletions have been described but their association with spermatogenic failure is unclear. Here we screened a total of 339 men with idiopathic spermatogenic failure, and 256 normozoospermic ancestry-matched men for chromosome microdeletions including AZFa, AZFb, AZFc, and the AZFc partial deletions (gr/gr, b1/b3 and b2/b3).