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Taylor and Francis Group, Cell Cycle, 11(9), p. 2085-2091

DOI: 10.4161/cc.9.11.11809

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Dependence receptors: mechanisms of an announced death

Journal article published in 2010 by Chantal Thibert ORCID, Joanna Fombonne
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Present adress Chantal Thibert : Université Joseph Fourrier, Grenoble F-38042, France, INSERM U836, Grenoble Institut des Neurosciences, Team 2 Neurodegenerescence and Plasticity ; International audience ; Dependence receptors form a family of functionally related receptors which are all able to induce two completely opposite intracellular signals depending on the availability of their ligand. Indeed, in its presence, they mediate a positive, classical signal transduction of survival, differentiation or migration but without it, they trigger a negative signal which leads to cell death. The molecular mechanisms involved in triggering cell death in the absence of ligand are starting to be unravelled: dependence receptors are recruited at well-defined domains at the plasma membrane, they trigger cell death through a monomeric form, they are cleaved by caspases and they recruit a caspase activating complex.