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Taylor and Francis Group, Journal of Enzyme Inhibition and Medicinal Chemistry, 5(22), p. 632-637

DOI: 10.1080/14756360701485562

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Synthesis of new bisaryl cyclopentathiophene and thieno-cyclopentoxazolidine derivatives as potential cytotoxic agents

Journal article published in 2007 by Ziad Omran, Patrick Dallemagne ORCID, Sylvain Rault
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The synthesis of new bisaryl thienocyclopentoxazolidine derivatives was achieved through a Suzuki cross-coupling procedure with the aim to enhance the previously reported cytotoxicity of the series. The biological activity, evaluated in the NCI's in vitro human disease-oriented tumor cell line screening panel, was however partially conserved by the pharmacomodulations.