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Wiley, Angewandte Chemie International Edition, 12(54), p. 3740-3743, 2015

DOI: 10.1002/anie.201411978

Wiley, Angewandte Chemie, 12(127), p. 3811-3814, 2015

DOI: 10.1002/ange.201411978

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A Nuclear Singlet Lifetime of More than One Hour in Room-Temperature Solution

Journal article published in 2015 by Gabriele Stevanato, Joseph T. Hill‐Cousins, Pär Håkansson ORCID, Soumya Singha Roy, Lynda J. Brown, Richard C. D. Brown, Giuseppe Pileio, Malcolm H. Levitt ORCID
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Abstract

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude.