The present paper highlights the importance of a robust SCC mixture for the successful introduction of this innovative technology in the concrete industry. A methodology to quantify SCC mixture robustness is also proposed. A central composite design was carried out to mathematically model the influence of five mixture parameters and their coupled effects on deformability, passing and filling abilities and compressive strength of SCC mixtures. The target SCC mix composition, to be applied during full-scale tests in a precast factory, was selected to be the central point in the factorial design. The mixture parameters suggested by the Japanese SCC-designing method were adopted. The derived models were used to estimate SCC properties while mixture parameters variations were simulated, based on daily fluctuations inherent from production process. SCC robustness was assessed by measuring how frequently the properties of simulated mixes fall inside the acceptance intervals.