Multimorbidity, especially co-morbidity between mental and somatic disorders, represents a growing challenge in general practice. The solution is hardly evermore sophisticated guidelines. The practitioner must improve on basing the clinical assessment of the patient on specific functional ability and need of rehabilitation. This requires allocation of time to handle more than one problem at a time and a close cooperation of treatment between physician, patient and staff. This article points to patient education and involvement of relatives, the use of problem-solving techniques, collaborative care and use of telemedicine tools as possible solutions.