Published in
Elsevier, Tetrahedron: Asymmetry, 6-8(20), p. 747-753
DOI: 10.1016/j.tetasy.2009.02.020
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Synthesis of threitol ceramide and [14C]threitol ceramide, non-glycosidic analogues of the potent CD1d antigen α-galactosyl ceramide
Journal article published in 2009 by
Yoel R. Garcia Diaz,
Justyna Wojno,
Liam R. Cox,
Gurdyal S. Besra 
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Abstract
The synthesis of threitol ceramide, which is a non-glycosidic analogue of the potent CD1d antigen α-galactosyl ceramide, is described. The synthesis of a 14C-labelled threitol ceramide analogue is also presented. This radiolabelled analogue will allow the intracellular trafficking pattern/itinerary of this iNKT-CD1d cell agonist to be studied.