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Wiley, Angewandte Chemie International Edition, 52(53), p. 14424-14427, 2014

DOI: 10.1002/anie.201409014

Wiley, Angewandte Chemie, 52(126), p. 14652-14655, 2014

DOI: 10.1002/ange.201409014

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Racemic DNA crystallography

Journal article published in 2014 by Pradeep K. Mandal, Gavin W. Collie ORCID, Brice Kauffmann, Ivan Huc
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Racemates increase the chances of crystallization by allowing molecular contacts to be formed in a greater number of ways. With the advent of protein synthesis, the production of protein racemates and racemic-protein crystallography are now possible. Curiously, racemic DNA crystallography had not been investigated despite the commercial availability of L- and D-deoxyribo-oligonucleotides. Here, we report a study into racemic DNA crystallography showing the strong propensity of racemic DNA mixtures to form racemic crystals. We describe racemic crystal structures of various DNA sequences and folded conformations, including duplexes, quadruplexes, and a four-way junction, showing that the advantages of racemic crystallography should extend to DNA.