Two multilayer materials based on Ti-6Al-4V alloy have been processed by diffusion bonding at two different temperatures [1023 K and 1173 K (750 °C and 900 °C)]. The influence of the processing temperature on microstructure, texture, and mechanical properties of the two multilayer materials has been analyzed. Scanning electron microscopy, X-ray diffraction, electron backscatter diffraction, and shear tests have been used as experimental techniques. The multilayer laminate processed at the lowest temperature of 1023 K (750 °C) exhibits mainly transversal texture in the longitudinal plane, which provides an anisotropic mechanical behavior, showing higher shear modulus and maximum shear strength under one of the shear test directions considered. In contrast, diffusion bonding at 1173 K (900 °C) leads to basal/transversal texture because of the partial α → β → α transformation, which provides more isotropic mechanical properties. Accordingly, this laminate shows similar shear modulus and maximum shear strength in different shear test orientations.