Dissemin is shutting down on January 1st, 2025

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Springer, Infection, 6(42), p. 1033-1037, 2014

DOI: 10.1007/s15010-014-0690-5

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Detection and quantification of EBV, HHV-6 and CMV DNA in the gastrointestinal tract of HIV-positive patients

Journal article published in 2014 by F. Falasca, P. Maida, A. Gaeta, S. Verzaro, I. Mezzaroma, A. Fantauzzi, G. Donato, E. Bonci ORCID, C. Castilletti, G. Antonelli ORCID, O. Turriziani
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Human herpes viruses (HHVs) have been frequently detected in the gastrointestinal (GI) tract and may contribute to the development of gastric cancer. In the present study, the detection rate and viral load of Epstein Barr virus (EBV), HHV-6 and Cytomegalovirus (CMV) were assessed in the GI tract of human immunodeficiency virus (HIV) positive patients and of uninfected patients. The analysis revealed a significantly higher detection rate of EBV and HHV-6 in HIV-infected individuals than in uninfected subjects (88.5 vs 63 %; p = 0.03). Moreover, EBV DNA load was significantly higher in the stomach of HIV patients than in controls. These data suggest that the HIV infection status may increase the persistence of these viruses in the GI compartment. Intriguingly, CMV DNA was undetectable in all biopsy specimens analyzed.