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EMBO Press, The EMBO Journal, 14(33), p. 1511-1513, 2014

DOI: 10.15252/embj.201488980

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‘From blood to blood’: de-differentiation of hematopoietic progenitors to stem cells

Journal article published in 2014 by Carlos-Filipe Pereira ORCID, Ihor R. Lemischka, Kateri Moore
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.