A complete framework of chronostratigraphic, petrographic, geochemical and thermobarometric data allows a reinterpretation of the evolution of the Plio-Quaternary volcanism in Gran Canaria. Bulk-rock and mineral chemistry has been used to define P-T crystallization paths, based on clinopyroxene-melt thermobarometry. Mafic magmas mainly crystallized at mantle depths (17-22 km) with secondary fractionation at crustal levels (1.5-8.0 km), suggesting multistage magma ascent. Crystallization of evolved magmas took place at crustal depths (3-15 km). The complexity of the magmatic plumbing system increased in the last 1 Ma, as shown by the presence of reverse zoned clinopyroxenes in the lavas, with green diopside-hedenbergite cores surrounded by brown diopsidic rims. Petrographic and chemical features of such clinopyroxenes support a xenocrystic origin of the green cores, related to magma mixing or mingling processes between pre-existing colder evolved magmas and new batches of hot basic magmas. The evolution of the magmatic feeding system beneath Gran Canaria was affected by the long-term uplift of the island as a result of lithospheric flexure caused by loading of the neighbouring island of Tenerife. This uplift favoured the generation of giant landslides and nesting of the recent volcanic activity (the last 1 Ma) within landslide basins. The association of rifts, giant landslides and nested volcanism with a higher degree of magmatic differentiation is proposed to constrain the plumbing system model.