Wiley, Scandinavian Journal of Immunology, 4(46), p. 326-330, 1997
DOI: 10.1046/j.1365-3083.1997.d01-146.x
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DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.