Dynamic Self-Assembly of Polycationic Clusters Based on Cyclodextrins for pH-Sensitive DNA Nanocondensation and Delivery by Component Design
Journal article published in 2014 by
Laura Gallego‐Yerga,
M. José González‐Álvarez,
Natalia Mayordomo,
Francisco Santoyo‐González,
Juan M. Benito 
,
Carmen Ortiz Mellet,
Carmen Ortiz Mellet ,
Francisco Mendicuti,
José M. García Fernández
,
Carmen Ortiz Mellet,
Carmen Ortiz Mellet ,
Francisco Mendicuti,
José M. García Fernández
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Abstract
The ability of cyclodextrin-based polycationic cluster to undergo reversible DNA condensation and release in a physiologically useful pH window has been finely tuned by the installation of a capping xylylene moiety at the secondary face of the cyclooligosaccharide. This strategy can be exploited advantageously in the design of self-assembling nonviral gene-delivery systems from molecular entities.