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BioMed Central, Genome Medicine, 2(4), p. 13

DOI: 10.1186/gm312

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PTPN22 splice forms: a new role in rheumatoid arthritis

Journal article published in 2012 by Lina-Marcela Diaz-Gallo ORCID, Javier Martin
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Genetic variation in the protein tyrosine phosphatase non-receptor type gene 22 (PTPN22, encoding lymphoid tyrosine phosphatase, LYP) influences the risk of developing multiple autoimmune diseases, but the underlying mechanisms are not completely understood. In a recent study published in Genome Medicine, Ronninger et al. showed that there are differences in the expression of PTPN22 isoforms between peripheral blood mononuclear cells from rheumatoid arthritis patients and those of healthy controls. This study provides new insights into the role of PTPN22 in autoimmune diseases.