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Public Library of Science, PLoS ONE, 4(10), p. e0123693, 2015

DOI: 10.1371/journal.pone.0123693

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Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes

Journal article published in 2015 by Alexia Martínez de Paz ORCID, Alexia Martínez de Paz, Jose Vicente Sanchez-Mut, Jose Vicente Sanchez-Mut, Mireia Samitier-Martí, Paolo Petazzi, Mauricio Sáez ORCID, Karolina Szczesna, Dori Huertas, Manel Esteller, Juan Ausió
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome.